Why are systematic reviews important? They combine and synthesize various studies and their findings. Systematic reviews appraise the validity of the results and findings of the collected studies in an impartial way. They define clear objectives and reproducible methodologies. What is a Meta-analysis A systematic review is a detailed, systematic and transparent means of gathering, appraising and synthesising evidence to answer a well-defined question. A meta-analysis is a statistical procedure for combining numerical data from multiple separate studies. A meta-analysis should only ever be conducted in the context of a systematic review
Meta-analysis is a tool for quantitative systematic review of observational studies and controlled trials that weights available evidence based on the numbers of patients included, the effect size, and often statistical tests of agreement with other trial When appropriate, some systematic reviews include a meta-analysis, which uses statistical methods to combine data from multiple sources. A review might use quantitative data, or might employ a qualitative meta-synthesis, which synthesises data from qualitative studies. The combination of data from a meta-analysis can sometimes be visualised A systematic review begins with a problem statement and a research question or hypothesis. Questions for a meta-analysis are usually narrow, focusing, for example, on a particular type of intervention and specific outcomes. The careful definition of key constructs is critical for deciding whether a primary study qualifies for the synthesis
Distinguishing between a systematic review and meta-analysis is essential to understand the role each plays in presenting and analysing data and estimates of treatment effects. Often, novice researchers mistakenly use these terms synonymously Systematic review and meta-analysis: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics in Helicobacter pylori eradication Helicobacter . 2005 Jun;10(3):157-71. doi: 10.1111/j.1523-5378.2005.00307.x Definitions. It's common to confuse systematic and literature reviews because both are used to provide a summary of the existent literature or research on a specific topic. Regardless of this commonality, both types of review vary significantly Deciding when we can trust the findings of systematic reviews (and meta-analyses)?This is module two of seven critical appraisal training videos. In this sec.. Acommon type of submission at any Journal is a review of the published information related to a topic. These are often returned to their authors without review, usually because they are literature reviews rather than systematic reviews. There is a big difference between the two (Table 1)
Chapters 9, 10, 11, and 12 discuss meta-analyses and other synthesis methods.. Cochrane's glossary includes this definition for Meta-analysis:. The use of statistical techniques in a systematic review to integrate the results of included studies. Sometimes misused as a synonym for systematic reviews, where the review includes a meta-analysis To report a comparative systematic review and meta-analysis of prostatic artery embolization (PAE) and transurethral resection of the prostate (TURP) for the management of benign prostatic hyperplasia (BPH). A multi-database search for relevant literature was conducted on 15 July 2020 to include studies published on or before that date Furthermore, systematic reviews also attempt to identify if certain subtypes of evidence (eg, small negative studies) are absent from the literature; this so-called publication bias is an important cause of incorrect conclusions in narrative reviews. 3 Systematic reviews frequently, but not necessarily, use statistical methods, meta-analysis, to combine the data from the literature. Rustam Al-Shahi Salman: Systematic reviews and meta-analysis of trials and observational studies, methodological advice including graphical presentation of data. Click here. Prof Joanna Wardlaw: methodology of performing and reporting systematic reviews, particularly related to neuroimaging Definition of a systematic review: A systematic review is an in-detail, clear and systematic way of collecting, evaluating and synthesis of evidence that will answer your question of study. Definition of meta-analysis: Meta-analysis is a statistical approach or procedure for accumulating data in the form of values or numerical from different studies
Tags: integrative review, living systematic review, meta-analysis, mixed methods review, network meta-analysis, overview of reviews, qualitative review, rapid review, scoping review, Systematic Review, systematic review service, umbrella review Objective To assess the effectiveness of surgical vs conservative interventions on pain and function in patients with subacromial impingement syndrome. Design Systematic review and meta-analysis of randomized controlled trials. Setting Clinical setting. Participants Patients 18 years and older with subacromial impingement syndrome
Importance This review provides a comprehensive comparison of treatment outcomes between robot-assisted laparoscopic surgery (RLS) and conventional laparoscopic surgery (CLS) based on randomly-controlled trials (RCTs). Objectives We employed RCTs to provide a systematic review that will enable the relevant community to weigh the effectiveness and efficacy of surgical robotics in controversial. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of high-flow oxygen via nasal cannulae (HFNC) compared to non-invasive ventilation (NIV) and/or standard oxygen in patients with acute, hypoxemic respiratory failure. We reviewed randomized controlled trials from CENTRAL, EMBASE, MEDLINE, Scopus and the International Clinical Trials Registry Platform. a systematic review to estimate the secondary attack rate (SAR) and observed reproduction number (R obs) in different settings and to explore differences by age, symptom status, duration of exposure and household size. A total of 97 studies were identified, 45 of which met inclusion criteria for meta-analysis
A systematic review and meta-analysis of recovery in schizophrenia. Schizophr Bull . 2013;39(6):1296-1306. doi: 10.1093/schbul/sbs130 PubMed Google Scholar Crossref 5 Systematic reviews with network meta-analysis (NMA) are published with increasing frequency in the health care literature. Prior to 2008, very few systematic reviews contained a NMA ; however, there has been a marked increase, to mid-2012 Lee recorded 201 published networks .The statistical method has been available since 2002 [3, 4] and owes its origins to much earlier work [5, 6] Two systematic reviews 48, 49 and one meta‐analysis 50 have previously explored whether opioid‐inclusive anaesthesia may be associated with opioid‐induced hyperalgesia. Among the three papers, one review was inconclusive 49, another did not conduct any quantitative analyses 48 and the third was prone to many limitations 50 . Data sources A systematic search of Medline, Embase, CINAHL and SportDiscus. Eligibility criteria Only randomised controlled trials with RET ≥6 weeks in duration and dietary protein. This systematic review with meta-analysis was conducted to compare safety and efficiency of the two techniques. Methods: We performed evidence acquisition intensively from PubMed, Embase, and Cochrane Library. Available comparative studies that evaluated both techniques were identified
Our meta-analysis and systematic review revealed evidence that negative symptoms can be improved at least modestly with psychosocial and psychological interventions. Although guidelines have traditionally supported the use of CBT, findings from skills-based interventions (SBIs) suggest that the latter are likely to have comparative, if not enhanced utility, as long as the treatment is continued This systematic review and meta-analysis supports the use of respiratory protection. However, the existing evidence is sparse and findings are inconsistent within and across studies. Multicentre RCTs with standardized protocols conducted outside epidemic periods would help to clarify the circumstances under which the use of masks or respirators is most warranted Effect of blood‐flow restricted vs heavy‐load strength training on muscle strength: Systematic review and meta‐analysis. Grønfeldt et al. (2020) Low-load training (20-50% 1RM) with blood flow restriction produces strength gains that are not significantly different from strength training without blood flow restriction in more traditional intensity ranges (60-90% 1RM) Objective To determine the effectiveness of physical activity interventions involving mobile applications (apps) or trackers with automated and continuous self-monitoring and feedback. Design Systematic review and meta-analysis. Data sources PubMed and seven additional databases, from 2007 to 2020. Study selection Randomised controlled trials in adults (18-65 years old) without chronic.
Systematic Reviews Salpingectomy vs tubal ligation for sterilization: a systematic review and meta-analysis Author links open overlay panel Kerry Mills PhD a b Greg Marchand MD, FACS, FACOG, FICS a Katelyn Sainz MD a Ali Azadi MD, FACOG c Kelly Ware MS a Janelle Vallejo MS a Sienna Anderson BS a Alexa King BS a Asya Osborn BS a Stacy Ruther BS a Giovanna Brazil BS a Kaitlynne Cieminski BS a. Objective To evaluate the association of chocolate consumption with the risk of developing cardiometabolic disorders. Design Systematic review and meta-analysis of randomised controlled trials and observational studies. Data sources Medline, Embase, Cochrane Library, PubMed, CINAHL, IPA, Web of Science, Scopus, Pascal, reference lists of relevant studies to October 2010, and email contact with. Systematic Review vs. Literature Review It is common to confuse systematic and literature reviews as both are used to provide a summary of the existent literature or research on a specific topic. Even with this common ground, both types vary significantly The findings of this systematic review and meta-analysis support physical distancing of 1 m or more and provide quantitative estimates for models and contact tracing to inform policy. Optimum use of face masks, respirators, and eye protection in public and health-care settings should be informed by these findings and contextual factors. Robust randomised trials are needed to better inform the. Systematic review, Meta-analysis, and R. Just before the Christmas break, Ciara attended a three-day workshop on conducting Meta-Analyses in R using the metafor package. The workshop was facilitated by the author of the package, Wolfgang Viechtbauer, and covered everything from effect size calculations to network meta-analysis
, Ignacio Neumann 1 Department of Internal Medicine, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile Systematic reviews and meta-analysis can overcome important limitations that are inherent in traditional, narrative summaries of research. The process of conducting a systematic review is described. The book is organized according to the steps involved in conducting a meta-analysis within a systematic review This systematic review was designed to investigate the efficacy and safety of videolaryngoscopy compared with fibreoptic bronchoscopy for awake tracheal intubation. The intubation time was our primary outcome investigated; the pooled data analysis demonstrated that the use of videolaryngoscopy is probably associated with a shorter intubation time compared with fibreoptic bronchoscopy The present systematic review and meta-analysis was performed in accordance with the Cochrane Handbook for Systematic Reviews and Interventions. 5 Analysis is reported following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement in health care interventions
The role of renin-angiotensin-aldosterone system (RAAS) inhibitors, notably angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs), in the COVID-19 pandemic has not been fully evaluated. With an increasing number of COVID-19 cases worldwide, it is imperative to better understand the impact of RAAS inhibitors in hypertensive COVID patients We conducted systematic reviews and network meta‐analyses to compare the relative efficacy of triptans (alone or in combination with other drugs) for acute treatment of migraines compared with other triptan agents, non‐steroidal anti‐inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA), acetaminophen, ergots, opioids, or anti‐emetics Chlorhexidine gluconate (CHG) bathing of hospitalized patients may have benefit in reducing hospital-acquired bloodstream infections (HABSIs). However, the magnitude of effect, implementation fidelity, and patient-centered outcomes are unclear. In this meta-analysis, we examined the effect of CHG bathing on prevention of HABSIs and assessed fidelity to implementation of this behavioral.
A systematic review is as good as the quality of the studies included in the review. A systematic review can be independently replicated. The first systematic review in evidence of homeopathy was published in 2000. Systematic reviews often, but not always, use statistical techniques such as meta-analysis to combine results of the eligible studies The efficacy of multi-component positive psychology interventions: a systematic review and meta-analysis of randomized controlled trials. J. Happiness Stud. 21 , 357-390 (2020) 2 Systematic Review • Typical narrative reviews are: - descriptive, i.e., not hypothesis driven; - use an informal approach when selecting studies; - omit some studies. • Systematic reviews use a standardized methodology to select and assess evidence from different studies to answer a scientific question. • Systematic reviews may include a meta-analysis For these reasons, we planned a systematic review and meta-analysis comparing surgical treatment with other therapies, in order to identify the best treatment for these patients. Our meta-analysis included more than 700 patients showing that surgical treatment seems to be associated with a better survival compared to other treatments and should be considered where feasible
Critical appraisal example systematic review and meta-analysis 1. Appraisal of a systematic reviewAppraisal of a systematic review using a checklist: Notes andusing a checklist: Notes and ExampleExample Nouran Hamza, BSc Pharm, MSc, DPH Biostatistician 2 . The purpose of the present review was to test the null hypothesis of no difference in the implant failure rates, postoperative infection, and marginal bone loss for patients being rehabilitated using dental implants with immediate nonfunctional loading (INFL) compared to immediate functional loading (IFL), against the alternative hypothesis of a difference
This systematic review and meta-analysis was performed in consistent with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. 8 The protocol is prospectively. Background:Cross project defect prediction (CPDP) recently gained considerable attention, yet there are no systematic efforts to analyse existing empirical evidence.Objective:To synthesise literature to understand the state-of-the-art in CPDP with respect to metrics, models, data approaches, datasets and associated performances.Further, we aim to assess the performance of CPDP vs. within. This systematic review and meta-analysis has been planned to evaluate the efficacy and safety of aspirin as an adjunctive therapy in TBM patients. Methods. We conducted a systematic search of randomized controlled trials in patients with tubercular meningitis published till October 2019 in all major clinical journals
This systematic review with meta-analysis was conducted to compare safety and efficiency of the two techniques. METHODS: We performed evidence acquisition intensively from PubMed, Embase, and Cochrane Library. Available comparative studies that evaluated both techniques were identified Objective To evaluate the effectiveness of exercise compared with other conservative interventions in the management of lateral elbow tendinopathy (LET) on pain and function. Design Systematic review and meta-analysis. Methods We used the Cochrane risk-of-bias tool 2 for randomised controlled trials (RCTs) to assess risk of bias and the Grading of Recommendations Assessment, Development and.
Narrative and quantitative analyses are not mutually exclusive and aspects from narrative and meta-analyses can successfully be integrated into a systematic review. Meta-analysis: Meta-analysis combines the results from individual studies to increase power and precision in estimating the overall intervention effects Start studying Chapter 19: Systematic Reviews: Meta-Analysis and Metasynthesis. Learn vocabulary, terms, and more with flashcards, games, and other study tools
Portal venous system thrombosis can develop after bariatric surgery. A systematic review and meta-analysis was conducted to evaluate the incidence of portal venous system thrombosis after bariatric surgery and clarify the role of anticoagulation for the prevention of portal venous system thrombosis after bariatric surgery Keywords: melanoma, diagnosis, non-invasive technique, diagnostic performance, skin cancer, meta-analysis. Citation: Blundo A, Cignoni A, Banfi T and Ciuti G (2021) Comparative Analysis of Diagnostic Techniques for Melanoma Detection: A Systematic Review of Diagnostic Test Accuracy Studies and Meta-Analysis. Front We conducted a systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 26 Eligible studies met the following inclusion criteria: (1) evaluated an intervention designed to reduce ageism, (2) examined at least 1 ageism outcome in relation to older adults, (3) used a design with a comparison group. Objective To systematically review the literature exploring the impact of isolation on hospitalised patients who are infectious: psychological and non-psychological outcomes. Design Systematic review with meta-analysis. Data sources Embase, Medline and PsycINFO were searched from inception until December 2018. Reference lists and Google Scholar were also handsearched
. Systematic review and meta-analysis of dietary carbohydrate restriction in patients with type 2 diabetes. BMJ Open Diabete The major strength of the present meta-analysis is that we used the GRADE approach to a systematic review of high-quality randomized trials. We predefined a relevant clinical question to be answered, as well as the population, the comparator, and the outcomes
Meta-analysis is a statistical technique for combining the results of independent, but similar, studies to obtain an overall estimate of treatment effect. While all meta-analyses are based on systematic review of literature, not all systematic reviews necessarily include meta-analysis In this systematic review and meta-analysis, we provide a comprehensive assessment of the factors affecting the association between night-shift work and prostate cancer, specifically the night.
Objective To undertake a systematic review and meta-analysis to assess the impact of cardiac rehabilitation (CR) on physical activity (PA) levels of patients with heart disease and the methodological quality of these studies. Methods Databases (MEDLINE, EMBASE, CENTRAL, CINAHL, PsychINFO and SportDiscus) were searched without language restriction from inception to January 2017 for randomised. Systematic review and meta-analysis of the available literature revealed that there was a small but significant reduction in subjective pain scores when compared with placebo in patients experiencing acute pain. There was a significant difference in the effect size between oral and nonoral routes of administration This systematic review and meta-analysis was prospectively registered on PROSPERO (International prospective register of systematic reviews), registration CRD42017081016. The review was reported in accordance with the guidelines from the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement . Search strateg Objective To update the Cochrane review comparing the effects of home-based and supervised centre-based cardiac rehabilitation (CR) on mortality and morbidity, quality of life, and modifiable cardiac risk factors in patients with heart disease. Methods Systematic review and meta-analysis. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO and CINAHL were. This systematic review was reported according to the guidelines of the Meta‐analysis of Observational Studies in Epidemiology22 and Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement.23 The protocol of the systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO, CRD42020179780) on 17 April 2020
Efficacy of Ketoprofen Vs Ibuprofen and Diclofenac: A Systematic Review of the Literature and Meta-Analysis Fabiola Atzeni 1 , Pier Carlo Sarzi-Puttini 1 , Luigi Lanata 2 and Michela Bagnasco 2 , 1 Rheumatology Unit, University Hospital L Sacco, Milan, Italy, 2 Medical Department, Dompé SpA, Milan, Ital Efficacy of liposomal bupivacaine vs. traditional anaesthetic infiltration for pain management in total hip arthroplasty: a systematic review and meta-analysis. S.-C. Zhou, B.-G. Liu, Z.-H. Wang. Department of Anesthesia, Linyi Central Hospital, Shandong, China. email@example.com The effects of myo-inositol vs. metformin on the ovarian function in the polycystic ovary syndrome: a systematic review and meta-analysis. By. Physicians Weekly - April 22, 2021 - Advertisement - Recent studies have revealed that myo-inositol could be more influential in patients with polycystic ovary syndrome (PCOS) Benefits and Risks of Clopidogrel vs. Aspirin Monotherapy after Recent Ischemic Stroke: A Systematic Review and Meta-Analysis Maurizio Paciaroni , 1 Birsen Ince , 2 Bo Hu , 3 Jiann-Shing Jeng , 4 Kursad Kutluk , 5 Liping Liu , 6 Min Lou , 7 Vladimir Parfenov , 8 Ka Sing Lawrence Wong , 9 Babak Zamani , 10 Dara Paek , 11 Jung Min Han 11 et al. Michael del Aguila , 11 Shalini Girotra 1
Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis. Janus Christian Jakobsen 1,2, Kiran Kumar Katakam 1, Anne Schou 1, Signe Gade Hellmuth 1, Sandra Elkjær Stallknecht 1, Katja Leth-Møller 1, Maria Iversen 1, Marianne Bjørnø. The search identified 527 potential studies of which 10 studies were included in the systematic review and 9 in the meta-analysis. The meta-analysis showed that Pilates increased VO 2 max, with an effect size (ES) = 0.57 (95% CI: 0.15-1; I 2 = 63.5%, p = 0.018) for the Pilates group vs. the control and ES = 0.51 (95% CI: 0.26-0.76; I 2 = 67%, p = 0.002) for Pilates pre-post effect
Background Multiple sclerosis (MS) is a chronic disabling, demyelinating disease of the central nervous system and is often associated with psychiatric comorbidities. Some studies suggest increased prevalence of bipolar disorder (BD) in MS. Objective To conduct a systematic review and meta-analysis assessing the prevalence of BD in adults with MS. Methods We registered this review with. Eleven of 25 studies included in our systematic review and investigating the effect of garlic on blood pressure met the inclusion criteria for meta-analysis (Table 1) [11-21].Fourteen studies were excluded from meta-analysis: six had no placebo control group [24, 25, 28, 32, 34, 35], another six reported incomplete data for mean SBP, DBP or SD [23, 26, 27, 30, 31, 33], and another two. A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: An update. Eur Urol 2015;67:1066-1096. Crossref, Medline, Google Scholar; 12 Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis Abstract Background It is unclear if anaesthesia maintenance with propofol is advantageous or beneficial over inhalational agents
This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement . Electronic search, study selection, data extraction, and quality assessment was performed independently by two reviewers Porcine vs bovine surfactant therapy for preterm neonates with RDS: systematic review with biological plausibility and pragmatic meta-analysis of respiratory outcomes Ascanio Tridente 1 , 2 , Lucia De Martino 3 & This is the first systematic review and meta‐analysis to study the extent of newly diagnosed diabetes in COVID‐19 patients. We used robust and standard methods, and the search was comprehensive (including grey literature); the literature search, study screening, selection, data extraction and quality assessment were performed independently by two researchers, and the quality of most. METHODS: We performed a systematic review and meta-analysis of six randomized controlled trials and 19 observational studies, with the inclusion criteria being a comparative study between DOACs and warfarin in patients with CKD or dialysis patients from database inception until August 2020
Carvedilol appears to be more effective than propranolol in the treatment of portal hypertension in cirrhotic patients. Aim. To compare the effects of carvedilol vs. propranolol on systemic and splanchnic haemodynamics and to evaluate the advers This large systematic review and meta-analysis shows that in a relevant clinical domain of perioperative care TIVA provides a better patient experience compared to volatile anaesthesia with a high degree of confidence in the effect estimate . These promising findings will hopefully trigger the conduct of prospective validation studies Foot characteristics and mechanics are hypothesized to affect aetiology of several lower extremity musculoskeletal conditions, including knee osteoarthritis (KOA). The purpose of this systematic review was to identify the foot characteristics and mechanics of individuals with KOA. Five databases were searched to identify relevant studies on foot characteristics and mechanics in people with KOA